Searchable abstracts of presentations at key conferences in endocrinology

ea0092ps1-01-07 | Cancer | ETA2023

Type 2 diabetes and obesity are not likely to be risk factors for thyroid cancer

Grimmichova Tereza , Kuklikova Vlasta , Bulanova Barbora , Pacesova Petra , Vaclavikova Eliska , Moravcova Jitka , Novak Zdenek , Mastnikova Karolina , Vankova Marketa

Background: Patients with type 2 diabetes (T2DM) are generally known to have increased risk of various types of cancer. However, the studies addressing the association between T2DM and thyroid cancer are heterogeneous and inconclusive. The aim of our study was to evaluate the patients who have already undergone thyroid surgery with histologically confirmed results as the ‘gold standard’.Methods: A retrospective study in 102 patients (74 women a...

ea0092ps1-08-09 | Translational 1 | ETA2023

Identification of rare braf variants in thyroid nodules

Kuklikova Vlasta , Bulanova Barbora , Vaclavikova Eliska , Moravcova Jitka , Mastnikova Karolina , Vlcek Petr , Katra Rami , Novakova Kodetova Daniela , Lastuvka Petr , Bavor Petr , Drozenova Jana , Chovanec Martin , Vcelak Josef , Bendlova Bela

Objectives: The substitution BRAF p.V600E is the most common genetic cause of the papillary thyroid carcinoma (PTC) and represents more than 95% genetic variants in BRAF gene. Other rare variants in the BRAF gene include other substitutions (e.g. p.K601E), small deletions or insertions close to codon 600. The aim of this study was to analyze a large cohort of thyroid nodules for rare genetic variants in the BRAF gene.M...